Dr Kim Tang¹, Dr.  Jason Brown¹, Dr. Megan Grigg¹

¹Royal Brisbane And Women’s Hospital, , Australia

Abstract:

Severe burn induces inflammation and stress hormone response which leads to hypermetabolic and hypercatabolic state, which is characterized by a significant loss of lean body mass, persistent muscle weakness, tachycardia, early fatigue with normal activity, and delayed wound healing.

The testosterone analogue Oxandrolone is an anabolic agent, has been shown in several randomized controlled trials to reduce lean body mass loss after burn injury. Preservation of lean body mass correlates with improved physical function, accelerated wound healing, faster rehabilitation and return to normal activity. Furthermore, these effects have been shown to be maintained even after cessation of Oxandrolone.

This is a retrospective study reviewing all patients admitted to the Royal Brisbane and Women’s Hospital Professor Stuart Pegg Adult Burns Centre with burn of TBSA>30% over a three-year period between July 2017 to June 2020, evaluating the use of Oxandrolone, its effects on length of stay, changes in body mass index and time between surgeries, comparing to those who did not receive Oxandrolone; adjusting to TBSA and number of surgeries during admission.

References:

Li H., Guo Y., Yang Z., Roy M. & Guo Q. (2016)’The efficacy and safety of oxandrolone treatment for patient with severe burns: A systematic review and meta-analysis’; Burns 42; pp. 717-727

Jeschke M., Finnerty C., Suman O., Kulp G., Mlcak R. & Herndon D. (2007)’The effect of oxandrolone on the endocrinologic, inflammatory and hypermetabolic responses during the acute phase postburn’; Ann Surg 246 pp. 351-362

Biography:

General surgery registrar, recently passed the fellowship exam